Artemisia verlotorum Lamotte (Compositae), growing in almost all the northern hemisphere, is used in folk medicine of some countries of Tuscany, Italy, as a remedy for hypertension. The pharmacological evaluation of the responses evoked by an aqueous dried extract of Artemisia verlotorum on the blood pressure of anaesthetized rats and on in vitro rat isolated aortae showed a marked, but transient, hypotensive activity. This effect was mediated by a strong vasodilator action, closely linked to the release of endothelial nitric oxide and to the nitric oxide-guanosine 3'-5'-cyclic monophosphate (cGMP) pathway, caused by a muscarinic receptor agonism.
|Autori:||Martinotti E; Calderone V; Breschi MC; Bandini P; Cioni PL|
|Titolo:||Pharmacological action of aqueous crude extracts of Artemisia verlotorum Lamotte (Compositae)|
|Anno del prodotto:||1997|
|Digital Object Identifier (DOI):||10.1002/(SICI)1099-1573(199712)11:8<612::AID-PTR167>3.3.CO;2-5|
|Appare nelle tipologie:||1.1 Articolo in rivista|