Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b,c and 19i showed a marked activity against Mycobacterium tuberculosis H(37)Rv. For this series of compounds, submitted to biological screening, no structure-activity relationship can be deduced.
|Autori:||P.L. Ferrarini; C. Mori; M. Badawneh; MANERA C; G. Saccomanni|
|Titolo:||Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives|
|Anno del prodotto:||1998|
|Digital Object Identifier (DOI):||10.1016/S0014-827X(98)00094-9|
|Appare nelle tipologie:||1.1 Articolo in rivista|