The aim of this study was to evaluate the agreement between the glomerular filtration rate (GFR) and an estimate of creatinine clearance (C-Cr), calculated from the values of body cell mass (BCM) and of plasma creatinine (P-Cr), thus avoiding urine collection. The value of BCM was obtained from the measurement of total body impedance in 80 renal patients. The relationship between 24-hour urinary creatinine excretion and BCM was evaluated in 30 of these patients. Body cell mass C-Cr (ml/min) was then calculated in each of the remaining 50 patients. For comparison, 24-hour C-Cr was measured in the same patients. The correlation coefficient of BCM C-Cr with GFR was 0.961, while that of 24-hour C-Cr with GFR was 0.869. Also, the agreement with GFR was better for BCM C-Cr than for 24-hour C-Cr. In conclusion, creatinine clearance predicted from body cell mass and plasma creatinine is a better indicator of renal function than measured 24-hour creatinine clearance.

Creatinine clearance predicted from body cell mass is a good indicator of renal function

DONADIO, CARLO;TRAMONTI, GIANFRANCO;
1997-01-01

Abstract

The aim of this study was to evaluate the agreement between the glomerular filtration rate (GFR) and an estimate of creatinine clearance (C-Cr), calculated from the values of body cell mass (BCM) and of plasma creatinine (P-Cr), thus avoiding urine collection. The value of BCM was obtained from the measurement of total body impedance in 80 renal patients. The relationship between 24-hour urinary creatinine excretion and BCM was evaluated in 30 of these patients. Body cell mass C-Cr (ml/min) was then calculated in each of the remaining 50 patients. For comparison, 24-hour C-Cr was measured in the same patients. The correlation coefficient of BCM C-Cr with GFR was 0.961, while that of 24-hour C-Cr with GFR was 0.869. Also, the agreement with GFR was better for BCM C-Cr than for 24-hour C-Cr. In conclusion, creatinine clearance predicted from body cell mass and plasma creatinine is a better indicator of renal function than measured 24-hour creatinine clearance.
1997
Donadio, Carlo; Lucchesi, A; Tramonti, Gianfranco; Bianchi, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/176614
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