The title compounds were prepared and tested as xanthine oxidase (XO) inhibitors. Results evidenced that potency was related to the position of the oxygen atom in the 2-linear chain and that it grew with distance from the sulfur atom until it became equipotent to 2-n-hexylthiohypoxanthine. Enzymatic oxidation on C(2) occurred in the 8-alkylthiohypoxanthines. On the contrary, oxidation on C(8) did not occur in the 2-alkythioderivatives, demonstrating that the chain forced these molecules to form a complex with molybdenum(VI) involving only the N(3) and N(9) nitrogen atoms.
|Autori:||G. BIAGI; I. GIORGI; F. PACCHINI; LIVI O; V.SCARTONI|
|Titolo:||2-ALKYLOXYALKYLTHIOHYPOXANTHINES AS NEW POTENT INHIBITORS OF XANTHINE OXIDASE|
|Anno del prodotto:||2001|
|Digital Object Identifier (DOI):||10.1016/S0014-827X(01)01160-0|
|Appare nelle tipologie:||1.1 Articolo in rivista|