Several 2,7-di(N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives were synthesized and tested for their ability to inhibit human platelet aggregation in vitro induced by arachidonic acid, collagen and ADP. Only five compounds showed any appreciable activity, and the results of all the active derivatives were similar to those of papaverine in the test with arachidonic acid and collagen. Moreover, the most active compounds were investigated in the test with ADP and again showed a significant activity. The tested compounds that possessed the best activity were also shown to increase the c-AMP level significantly without involving the adenylyl cyclase system. (C) 2001 Elsevier Science S.A. All rights reserved.
|Autori interni:||MANERA, CLEMENTINA|
|Autori:||FERRARINI P; M. BADAWNEH; F. FRANCONI; C. MANERA; M. MICELI; C. MORI; G. SACCOMANNI|
|Titolo:||Synthesis and antiplatelet activity of some 2,7-di(N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives|
|Anno del prodotto:||2001|
|Digital Object Identifier (DOI):||10.1016/S0014-827X(01)01075-8|
|Appare nelle tipologie:||1.1 Articolo in rivista|