Purpose of the present investigation was to evaluate six terpene-containing essential oils for their capacity to promote permeation of estradiol (ES) through hairless mouse skin in vitro. Tests on cajuput, cardamom, melissa. myrtle, niaouli and orange oil, all used at the 10% w/w concentration in propylene glycol (PG), evidenced niaouli oil (NIA) as the best permeation promoter for ES. Tests on the main terpene components of NIA (1.8 cineole, alpha-pinene, alpha-terpineol and D-limonene). evaluated neat (10% w/w in PG) or in admixture. confirmed the better promoting activity of whole NIA. The present data point to the validity of complex terpene Mixtures. Such as that composing NIA, as transdermal penetration enhancers for moderately lipophilic drugs like ES.

Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin

MONTI, DANIELA;CHETONI, PATRIZIA;BURGALASSI, SUSI;
2002-01-01

Abstract

Purpose of the present investigation was to evaluate six terpene-containing essential oils for their capacity to promote permeation of estradiol (ES) through hairless mouse skin in vitro. Tests on cajuput, cardamom, melissa. myrtle, niaouli and orange oil, all used at the 10% w/w concentration in propylene glycol (PG), evidenced niaouli oil (NIA) as the best permeation promoter for ES. Tests on the main terpene components of NIA (1.8 cineole, alpha-pinene, alpha-terpineol and D-limonene). evaluated neat (10% w/w in PG) or in admixture. confirmed the better promoting activity of whole NIA. The present data point to the validity of complex terpene Mixtures. Such as that composing NIA, as transdermal penetration enhancers for moderately lipophilic drugs like ES.
2002
Monti, Daniela; Chetoni, Patrizia; Burgalassi, Susi; Najarro, M; Saettone, Mf; Boldrini, E.
File in questo prodotto:
File Dimensione Formato  
Arpi 178029.pdf

solo utenti autorizzati

Tipologia: Versione finale editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 71.77 kB
Formato Adobe PDF
71.77 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/178029
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 68
  • ???jsp.display-item.citation.isi??? 52
social impact