Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([H-3]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [H-3]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
|Autori interni:||DELL'OSSO, LILIANA|
|Autori:||MARAZZITI D; DELL'OSSO L; ROSSI A; MASALA T; BARONI S; ARMANI A; GIANNACCINI G; DI NASSO E; LUCACCHINI A; CASSANO GB|
|Titolo:||Decreased platelet [H-3]paroxetine binding sites in suicide attempters|
|Anno del prodotto:||2001|
|Digital Object Identifier (DOI):||10.1016/S0165-1781(01)00281-5|
|Appare nelle tipologie:||1.1 Articolo in rivista|