Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([H-3]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [H-3]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Decreased platelet [H-3]paroxetine binding sites in suicide attempters

DELL'OSSO, LILIANA;ROSSI, ALESSANDRA;GIANNACCINI, GINO;LUCACCHINI, ANTONIO;
2001-01-01

Abstract

Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([H-3]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [H-3]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Marazziti, D; Dell'Osso, Liliana; Rossi, Alessandra; Masala, T; Baroni, S; Armani, A; Giannaccini, Gino; DI NASSO, E; Lucacchini, Antonio; Cassano, Gb
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/178075
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 21
social impact