In situ formation of immune complexes is a well recognized mechanism of renal injury in systemic autoimmune disorders. The identification of intrinsic renal antigens that are targets of nephritogenic antibodies is a field of active investigation. Recently, two proteins expressed in the kidney have been characterized as renal antigens. Alpha-actinin, an actin-binding protein localized in glomerular podocytes, is the major target of nephritogenic anti-DNA antibodies. Alpha-enolase, a glycolytic enzyme, is a target of nephritogenic anti-DNA and non-anti-DNA antibodies.
|Autori interni:||MIGLIORINI, PAOLA|
|Autori:||MIGLIORINI P; PRATESI F; BONGIORNI F; MOSCATO S; SCAVUZZO M; BOMBARDIERI S.|
|Titolo:||The targets of nephritogenic antibodies in systemic autoimmune disorders|
|Anno del prodotto:||2002|
|Digital Object Identifier (DOI):||10.1016/S1568-9972(02)00028-9|
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