Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.
|Autori:||BLANDIZZI C; MALIZIA T; BATONI G; GHELARDI E; BASCHIERA F; BRUSCHINI P; SENESI S; CAMPA M; DEL TACCA M|
|Titolo:||Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients|
|Anno del prodotto:||2002|
|Digital Object Identifier (DOI):||10.1128/AAC.46.5.1594-1596.2002|
|Appare nelle tipologie:||1.1 Articolo in rivista|