A new and practical way to introduce an alkyl fragment in the β-position of aliphatic carboxylic acid derivatives with high enantioselectivities by the use of a commercially available chiral ligand is reported. N-Acyl pyrrolidinones, as simple derivatives of an α,β-unsaturated carboxylic acid, were found to be the substrates of choice featuring good reactivity and high enantioselectivities (up to >99% ee).
Highly EnantioselctiveCoper-Phosporamidite-Catalyzed Coniugate Addition of Dialkylzinc Reagent to Acyclic alfa-beta-Unsaturated Imides
PINESCHI, MAURO;DI BUSSOLO, VALERIA;
2006-01-01
Abstract
A new and practical way to introduce an alkyl fragment in the β-position of aliphatic carboxylic acid derivatives with high enantioselectivities by the use of a commercially available chiral ligand is reported. N-Acyl pyrrolidinones, as simple derivatives of an α,β-unsaturated carboxylic acid, were found to be the substrates of choice featuring good reactivity and high enantioselectivities (up to >99% ee).File in questo prodotto:
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