alpha-Synuclein is a presynaptic protein involved in various degenerative disorders now defined as synucleinopathies. These include neurological diseases that share a few pathological features consisting of aggregates of both normal and altered alpha-synuclein within specific neuronal populations and/or glial cells. The prototype of synucleinopathies is represented by Parkinson's disease (PD) in which alpha-synuclein is identified as a constant component of neuronal pale eosinophilic inclusions: "the Lewy Bodies." In the present article, we discuss the potential significance of amphetamine-induced overexpression of alpha-synuclein in light of clinical findings showing neurodegeneration following overexpression of alpha-synuclein and recent experimental studies that measured increased expression of alpha-synuclein following amphetamine derivatives.
|Autori interni:||PELLEGRINI, ANTONIO|
|Autori:||MAUCELI G; BUSCETI CI; PELLEGRINI A; SOLDANI P; LENZI P; PAPARELLI A; FORNAI F|
|Titolo:||Overexpression of alpha-synuclein following methamphetamine: is it good or bad?|
|Anno del prodotto:||2006|
|Appare nelle tipologie:||1.1 Articolo in rivista|