A simple efficient, stereoselective, and regioselective method for the synthesis of beta-chlorohydrins, beta-bromohydrins, and beta-iodohydrins by the direct opening of 1,2-epoxides with the corresponding ammonium halide in acetonitrile, in the presence of metal salts. is described. This new method appears to be of general use and competitive with the other methods previously reported.
REGIOSELECTIVE AND STEREOSELECTIVE SYNTHESIS OF BETA-HALOHYDRINS FROM 1,2-EPOXIDES WITH AMMONIUM HALIDES IN THE PRESENCE OF METAL-SALTS
CROTTI, PAOLO;
1992-01-01
Abstract
A simple efficient, stereoselective, and regioselective method for the synthesis of beta-chlorohydrins, beta-bromohydrins, and beta-iodohydrins by the direct opening of 1,2-epoxides with the corresponding ammonium halide in acetonitrile, in the presence of metal salts. is described. This new method appears to be of general use and competitive with the other methods previously reported.File in questo prodotto:
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