Hydrophilic polystyrene (PS) type resins displaying excellent adsorption capacity towards aromatic molecules in water were obtained by carrying out the chemical modification of mesoporous crosslinked PS–type resins with a variety of hydrophilic reagents. The vinyl groups available on the surface of the resin beads were utilized as reactive sites for free radical grafting of hydrophilic moieties. Qualitative and semi-quantitative assessment of the functionalization degree was performed by FT-IR spectroscopic analysis. Wetting and water uptake tests confirmed the occurrence of functionalization. The removal of an acridine virucide agent by the modified PS resins was tested under physiological conditions at pH 7.4. The virucide uptake capacity of the modified resins resulted excellent and in some cases almost quantitative. The antipyrogen treatment at 180 °C for 8 hours did not significantly affect the resin hydrophilicity although a slight decrease of the adsorption capacity was detected. Some of the modified resins seem to be very promising for application in hemofiltration procedures, where they can be used as virucide sorbents during the antivirucidal stage. On the other hand, the reaction of chloromethyl groups of Merrifield-type resins with hydrophilic polyols did not improve the virucide adsorption of the crosslinked PS resin.
|Autori:||I. BARTOLOZZI; SOLARO R; E. CHIELLINI; G. MARI|
|Titolo:||Polymeric Sorbents for Virucide Agents in Blood Treatments|
|Anno del prodotto:||2007|
|Digital Object Identifier (DOI):||10.1177/0883911507080264|
|Appare nelle tipologie:||1.1 Articolo in rivista|