A simple method for the stereoselective synthesis of substituted 3-aryl-2,3-dihydrobenzofurans, e.g., I, by intramol. cyclization of hydroxyphenols is described. The stereoselective ortho-C-alkylation of phenols provided a stereoselective access to a diverse array of polyfunctionalized products contg. a diarylmethane stereogenic center without the need for time-consuming protection-deprotection steps.
Synthesis and Cyclodehydration of Hydroxyphenols: A New Stereoselective Approach to 3-Aryl-2,3-dihydrobenzofuranes
CROTTI, PAOLO;DI BUSSOLO, VALERIA;PINESCHI, MAURO
2007-01-01
Abstract
A simple method for the stereoselective synthesis of substituted 3-aryl-2,3-dihydrobenzofurans, e.g., I, by intramol. cyclization of hydroxyphenols is described. The stereoselective ortho-C-alkylation of phenols provided a stereoselective access to a diverse array of polyfunctionalized products contg. a diarylmethane stereogenic center without the need for time-consuming protection-deprotection steps.File in questo prodotto:
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