The new and fully engineered version of the YAP-(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPELT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPELT modalities alone. The scanner is made up of four detector heads, each one composed of a 4 x 4 cm(2) of YAlO3:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 em axially x 4 cm circle divide transaxially. In PET mode, the volume resolution is less than 8 mm 3 and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPELT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP-PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPELT modalities. (c) 2006 Elsevier B.V. All rights reserved.
Preliminary assessment of the imaging capability of the YAP-(S)PET small animal scanner in neuroscience
BELCARI, NICOLA;DEL GUERRA, ALBERTO
2006-01-01
Abstract
The new and fully engineered version of the YAP-(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPELT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPELT modalities alone. The scanner is made up of four detector heads, each one composed of a 4 x 4 cm(2) of YAlO3:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 em axially x 4 cm circle divide transaxially. In PET mode, the volume resolution is less than 8 mm 3 and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPELT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP-PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPELT modalities. (c) 2006 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
