The aim of the study was to evaluate the influence of high values of blood pressure on circulating CXCL10. CXCL10 levels (median; interquartile range (IQR)) were significantly higher in patients with high systolic and diastolic blood pressure (n = 48; 159 (125-185) pg ml(-1)) than in controls (n = 127; 98 (71-115) pg ml(-1)) or in patients with only systolic hypertension (n = 79; 125 (84-187) pg ml(-1)) (P<0.0001); in multiple linear regression models using CXCL10 as dependent variable, and age and systolic or diastolic blood pressure as covariates, only systolic or diastolic blood pressures were significantly (P<0.0001) related to CXCL10 levels. The results of this study demonstrate increased serum CXCL10 levels in patients with hypertension.
High serum levels of CXC chemokine ligand 10 in untreated essential hypertension
ANTONELLI, ALESSANDRO;Fallahi P;Ferrari SM;GHIADONI, LORENZO;TADDEI, STEFANO;FERRANNINI, ELEUTERIO
2008-01-01
Abstract
The aim of the study was to evaluate the influence of high values of blood pressure on circulating CXCL10. CXCL10 levels (median; interquartile range (IQR)) were significantly higher in patients with high systolic and diastolic blood pressure (n = 48; 159 (125-185) pg ml(-1)) than in controls (n = 127; 98 (71-115) pg ml(-1)) or in patients with only systolic hypertension (n = 79; 125 (84-187) pg ml(-1)) (P<0.0001); in multiple linear regression models using CXCL10 as dependent variable, and age and systolic or diastolic blood pressure as covariates, only systolic or diastolic blood pressures were significantly (P<0.0001) related to CXCL10 levels. The results of this study demonstrate increased serum CXCL10 levels in patients with hypertension.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
