The aim of the study was to evaluate the influence of high values of blood pressure on circulating CXCL10. CXCL10 levels (median; interquartile range (IQR)) were significantly higher in patients with high systolic and diastolic blood pressure (n = 48; 159 (125-185) pg ml(-1)) than in controls (n = 127; 98 (71-115) pg ml(-1)) or in patients with only systolic hypertension (n = 79; 125 (84-187) pg ml(-1)) (P<0.0001); in multiple linear regression models using CXCL10 as dependent variable, and age and systolic or diastolic blood pressure as covariates, only systolic or diastolic blood pressures were significantly (P<0.0001) related to CXCL10 levels. The results of this study demonstrate increased serum CXCL10 levels in patients with hypertension.
|Autori:||Antonelli, Alessandro; Fallahi, P; Rotondi, M; Ferrari, Sm; Romagnani, P; Ghiadoni, Lorenzo; Serio, M; Taddei, Stefano; Ferrannini, Eleuterio|
|Titolo:||High serum levels of CXC chemokine ligand 10 in untreated essential hypertension|
|Anno del prodotto:||2008|
|Digital Object Identifier (DOI):||10.1038/jhh.2008.15|
|Appare nelle tipologie:||1.1 Articolo in rivista|