We measured parathyroid hormone levels in pregnant and nonpregnant women and at 1,2 and 5 days of life in healthy term neonates and in hypocalcemic preterm infants using a new immunoradiometric assay which measures only biologically active intact parathyroid hormone and by a mid-molecule parathyroid hormone radioimmunoassay. During pregnancy intact and mid-molecule parathyroid hormone levels did not show any modification and were not different from parathyroid hormone levels of nonpregnant age-matched controls. Serum calcium and phosphorus levels did not vary during each trimester of pregnancy. In cord serum intact and mid-molecule parathyroid hormone values were low in both term and preterm infants. In term neonates intact and mid-molecule parathyroid hormone levels peaked on day 1; in preterm infants intact parathyroid hormone levels peaked on day 1 while mid-molecule parathyroid hormone values peaked on day 2. Intact parathyroid hormone levels showed a more marked increase in preterm (19-fold) than in term neonates (7.5-fold) on day 1. Our data do not confirm the previously reported "physiologic" hyperparathyroidism in pregnancy. Moreover we found a normal parathyroid gland responsiveness to decreasing serum calcium levels in the first days of life in term and preterm infants. Our results suggest that measurement of intact parathyroid hormone 1-84 by immunora-diometric assay in the first days of life is a more sensitive index of parathyroid gland secretory function than the measurement of middle or carboxyl-terminal parathyroid hormone fragments allowing the detection of the dynamic changes of parathyroid hormone which occur in hypocalcemic preterm infants.
|Autori interni:||SAGGESE, GIUSEPPE|
|Autori:||SAGGESE G; BARONCELLI GI; BERTELLONI S; CIPOLLONI C|
|Titolo:||Intact parathyroid-hormone levels during pregnancy, in healthy term neonates and in hypocalcemic preterm infants|
|Anno del prodotto:||1991|
|Digital Object Identifier (DOI):||10.1111/j.1651-2227.1991.tb11726.x|
|Appare nelle tipologie:||1.1 Articolo in rivista|