A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of beta-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described. This new method appears to be competitive with the other methods previously reported.
EASY DIRECT STEREOSELECTIVE AND REGIOSELECTIVE FORMATION OF BETA-HYDROXY NITRILES BY REACTION OF 1,2-EPOXIDES WITH POTASSIUM CYANIDE IN THE PRESENCE OF METAL-SALTS
CROTTI, PAOLO;FAVERO, LUCILLA;
1991-01-01
Abstract
A simple efficient, anti stereoselective, and highly regioselective method for the synthesis of beta-hydroxy nitriles by the direct opening of 1,2-epoxides with KCN in acetonitrile, in the presence of metal salts, is described. This new method appears to be competitive with the other methods previously reported.File in questo prodotto:
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