[GRAPHICS] The reaction of the vinyl oxirane 1 derived from D-glucal with a series of 0-nucleophiles (alcohols, phenol, and diacetone D-glucose) affords the corresponding 2-unsaturated beta-O-glycosides in a completely stereoselective way (syn 1,4-addition pathway). Epoxide 1 is generated in situ by treatment of the corresponding hydroxy mesylate 2 with t-BuOK in anhydrous benzene.
New stereoselective beta-glycosylation via a vinyl oxirane derived from D-glucal
DI BUSSOLO, VALERIA;PINESCHI, MAURO;CROTTI, PAOLO
2002-01-01
Abstract
[GRAPHICS] The reaction of the vinyl oxirane 1 derived from D-glucal with a series of 0-nucleophiles (alcohols, phenol, and diacetone D-glucose) affords the corresponding 2-unsaturated beta-O-glycosides in a completely stereoselective way (syn 1,4-addition pathway). Epoxide 1 is generated in situ by treatment of the corresponding hydroxy mesylate 2 with t-BuOK in anhydrous benzene.File in questo prodotto:
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