This paper reports synthesis and characterization, by spectroscopic methods, of three new N-methyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine isomers 3a, 3b and 3c. For comparison purpose the 3-benzyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine (7) was also prepared. Starting from the isomer mixture 3a–c and the chloroderivative 7, by nucleophilic substitution reaction with ethyl carbazate and subsequent intramolecular cyclization, the new tricyclic derivatives 5a–c and 9 were prepared and tested towards the benzodiazepine and adenosine A1 and A2A receptors.
CHARACTERIZATION AND PRELIMINARY EMPLOYMENT OF 1-, 2- AND 3-METHYL-5-PHENYL-7-CHLORO-1,2,3-TRIAZOLO[4,5-D]PYRIMIDINE
GIORGI, IRENE;
2003-01-01
Abstract
This paper reports synthesis and characterization, by spectroscopic methods, of three new N-methyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine isomers 3a, 3b and 3c. For comparison purpose the 3-benzyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine (7) was also prepared. Starting from the isomer mixture 3a–c and the chloroderivative 7, by nucleophilic substitution reaction with ethyl carbazate and subsequent intramolecular cyclization, the new tricyclic derivatives 5a–c and 9 were prepared and tested towards the benzodiazepine and adenosine A1 and A2A receptors.File in questo prodotto:
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