A procedure is described for the preparation of (S)-dolichol and (S)-nordolichol starting from the polyprenyl fraction extracted from Gingko Biloba integer or exhausted leaves. The procedure appears extremely valuable to obtain the two chiral isoprenoid compounds in good chemical yields and retention of high degree of enantiomeric excess. Also, the (S)-nordolichol represents a good chiral precursor for the preparation of 14C-labelled (S)-dolichol to be used in biological investigations on the (S)-dolichol catabolism in the functional living cell. Furthermore, the possible role of (S)-dolichol as a free radical scavenger in the cell membrane was preliminarily evaluated by means of a 1H-NMR analytical method. Apparently, experimental results substantiate this hypothesis.
|Autori:||BIZZARRI R; CERBAI B; SIGNORI F; SOLARO R; BERGAMINI E; TAMBURINI I; CHIELLINI E|
|Titolo:||New Perspectives for (S)-Dolichol and (S)-Nordolichol Synthesis and Biological Functions|
|Anno del prodotto:||2003|
|Appare nelle tipologie:||1.1 Articolo in rivista|