Six new lupane (1-4) and oleanane saponins (5 and 6) were isolated from the aerial parts of Schefflera fagueti Baill. (Araliaceae). Their structures were determined by 2D-NMR spectroscopy (DQF-COSY, 1D-TOCSY, 2D-HOHAHA, 1D-ROESY, HSQC, HMBC). The antiproliferative activity of compounds 1-6 and of their prosapogenins (1a-6a) was evaluated using three continuous murine and human culture cell lines J774, HEK-293, WEHI-164. Oleanane saponins 5 and 6 were the most active, showing significant inhibitory effects on all cell lines, while their prosapogenins 5a and 6a demonstrated minor activity.
|Autori:||G. CIOFFI; A. BRACA; G. AUTORE; MORELLI I; A. PINTO; F. VENTURELLA; N. DE TOMMASI|
|Titolo:||Cytotoxic saponins from Schefflera fagueti|
|Anno del prodotto:||2003|
|Appare nelle tipologie:||1.1 Articolo in rivista|