Objective: To evaluate the effect of growth hormone treatment on final height, phosphate metabolism, bone markers, and bone mineral density in children with X-linked hypophosphatemic rickets. Study design: Six patients (aged 7.8 +/- 1.8 years; height,- score, 3.4 +/- 0.5) received conventional treatment (1,25-dihydroxyvitamin D-3 plus phosphate salts) combined with growth hormone (0.6-0.9 IU/kg per week, subcutaneously) (group A); 6 patients (aged 7.9 +/- 2.5 years; height z score, -2.1 +/- 0.6, P <.01 with respect to group A) received only conventional treatment (group B). Results: Final height z score significantly improved in group A (-2.4 +/- 0.5, P <.03 with respect to the value at entry), whereas it did not change in group B (-2.8 +/- 0.5, P = NS). At final height, degree of body disproportion was similar between the groups (group A, 1.3 +/- 0.2; group B, 1.2 +/- 0.1; P = NS). Phosphate retention, bone markers, and radial bone mineral density increased only in group A. No adverse effects were observed. Conclusions: In poorly growing patients with X-linked hypophosphatemic rickets, growth hormone therapy combined with conventional treatment improves final height, phosphate retention, and radial bone mineral density, but it does not influence degree of body disproportion.
|Autori:||BARONCELLI GI; BERTELLONI S; CECCARELLI C; SAGGESE G|
|Titolo:||Effect of growth hormone treatment on final height, phosphate metabolism, and bone mineral density in children with X-linked hypophosphatemic rickets|
|Anno del prodotto:||2001|
|Digital Object Identifier (DOI):||10.1067/mpd.2001.108955|
|Appare nelle tipologie:||1.1 Articolo in rivista|