Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A(1)-adenosine receptor (A(1)AR) ligands

The synthesis of a new family of A1-adenosine receptor (A1AR) ligands 3a-n has been performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compounds bind the A1AR in a selective way over A2AAR and A3AR and one of them (3j) presents a very high affinity, probably due to the phenethylamine substituent at C-4.



Autori interni: 
MARTINI, CLAUDIA
TRINCAVELLI, MARIA LETIZIA
mostra contributor esterni 
Autori: SCHENONE S.; BRUNO O.; FOSSA P.; RANISE A.; MENOZZI G.; MOSTI L.; BONDAVALLI F.; MARTINI C.; TRINCAVELLI M.L.
Titolo: Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A(1)-adenosine receptor (A(1)AR) ligands
Anno del prodotto: 2001
Appare nelle tipologie:1.1 Articolo in rivista

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http://hdl.handle.net/11568/186351
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