SN 0042-4900 This preliminary study shows that both liquid and freeze-dried grapefruit juice increase the oral bioavailability of cyclosporine in dogs and suggests the possible use of grapefruit juice to decrease the dose of cyclosporine. This combined treatment could reduce the cost of cyclosporine treatment without the side effects associated with ketoconazole combination therapy. The fact that a single oral dose of freeze-dried grapefruit juice had the same effect as the liquid form suggests its possible use to increase the bioavailability of cyclosporine, with a good compliance in treated dogs. However, further studies on the effects of multiple dosing, breed, sex and age differences are needed before this combined treatment can be put into clinical practice.
Effect of grapefruit juice on the pharmacokinetics of cyclosporine in dogs
MEUCCI, VALENTINA;GIUSIANI, MARIO;SOLDANI, GIULIO;CORAZZA, MICHELE;GIORGI M.
2004-01-01
Abstract
SN 0042-4900 This preliminary study shows that both liquid and freeze-dried grapefruit juice increase the oral bioavailability of cyclosporine in dogs and suggests the possible use of grapefruit juice to decrease the dose of cyclosporine. This combined treatment could reduce the cost of cyclosporine treatment without the side effects associated with ketoconazole combination therapy. The fact that a single oral dose of freeze-dried grapefruit juice had the same effect as the liquid form suggests its possible use to increase the bioavailability of cyclosporine, with a good compliance in treated dogs. However, further studies on the effects of multiple dosing, breed, sex and age differences are needed before this combined treatment can be put into clinical practice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
