Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compds. was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compds. 7 and 8, having betulinic acid as aglycon, were the most active constituents.
|Autori interni:||BRACA, ALESSANDRA|
|Autori:||A. BRACA; G. AUTORE; F. DE SIMONE; S. MARZOCCO; MORELLI I; F. VENTURELLA; N. DE TOMMASI|
|Titolo:||Cytotoxic Saponins from Schefflera rotundifolia|
|Anno del prodotto:||2004|
|Digital Object Identifier (DOI):||10.1055/s-2004-832623|
|Appare nelle tipologie:||1.1 Articolo in rivista|