Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compds. was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compds. 7 and 8, having betulinic acid as aglycon, were the most active constituents.

Cytotoxic Saponins from Schefflera rotundifolia

BRACA, ALESSANDRA;MORELLI, IVANO;
2004-01-01

Abstract

Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compds. was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compds. 7 and 8, having betulinic acid as aglycon, were the most active constituents.
2004
Braca, Alessandra; G., Autore; F., DE SIMONE; S., Marzocco; Morelli, Ivano; F., Venturella; N., DE TOMMASI
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/187269
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