Twenty-three kaurane-type diterpenes, including twenty new natural products, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chem. anal. The isolated compds. were tested for their cytotoxic activity towards a panel of cancer cell lines. I and the related compd. 10alfa,13alfa,17-trihydroxy-9alfa-methyl-15-oxo-20-norkauran-19-oic acid gamma-lactone showed activity against all cell lines with ED50 values in the range of 10-20 microg/mL. The previously known 13-hydroxy-15-oxozoapatlin was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concns. used.
|Autori:||BRACA A; ARMENISE A; MORELLI I; MENDEZ J; MI Q; CHAI HB; SWANSON SM; KINGHORN AD; DE TOMMASI N.|
|Titolo:||Structure of Kaurane-Type Diterpenes from Parinari sprucei and their Potential Anticancer Activity|
|Anno del prodotto:||2004|
|Digital Object Identifier (DOI):||10.1055/s-2004-827155|
|Appare nelle tipologie:||1.1 Articolo in rivista|