We report the study of a new class of adenosine receptor (AR) antagonists featuring the 2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazine nucleus bearing a free or functionalized amino group at the 5-position (APTBTs). Suitable combinations of substituents on the 5-amino moiety and at 9-position of the tricyclic nucleus allowed us to obtain new potent and selective A1 and A3AR antagonists.
2-PHENYL[1,2,3]TRIAZOLO[1,2-a]BENZOTRIAZIN-1-ONE DERIVATIVES AS A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS
DA SETTIMO PASSETTI, FEDERICO;TALIANI, SABRINA;SIMORINI, FRANCESCA;LA MOTTA, CONCETTINA;MARINI, ANNA MARIA;MARTINI, CLAUDIA;
2005-01-01
Abstract
We report the study of a new class of adenosine receptor (AR) antagonists featuring the 2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazine nucleus bearing a free or functionalized amino group at the 5-position (APTBTs). Suitable combinations of substituents on the 5-amino moiety and at 9-position of the tricyclic nucleus allowed us to obtain new potent and selective A1 and A3AR antagonists.File in questo prodotto:
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