GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.
|Autori:||SENSI E; TANCREDI M; ARETINI P; CIPOLLINI G; COLLECCHI P; NACCARATO AG; VIACAVA P; BEVILACQUA G; CALIGO MA|
|Titolo:||Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma|
|Anno del prodotto:||2004|
|Digital Object Identifier (DOI):||10.1023/B:BREA.0000041625.60280.4a|
|Appare nelle tipologie:||1.1 Articolo in rivista|