GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

NACCARATO, ANTONIO GIUSEPPE;BEVILACQUA, GENEROSO;
2004

Abstract

GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.
Sensi, E; Tancredi, M; Aretini, P; Cipollini, G; Collecchi, P; Naccarato, ANTONIO GIUSEPPE; Viacava, P; Bevilacqua, Generoso; Caligo, Ma
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/187973
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