PURPOSE:To explore the association of hepatitis C virus (HCV) infection with thyroid disorders. METHODS:We investigated the prevalence of thyroid disorders in 630 consecutive patients with chronic hepatitis due to HCV infection; all patients were free of cirrhosis and hepatocarcinoma, and were not on interferon treatment. Also included were a control group of 389 subjects from an iodine-deficient area, another control group of 268 persons living in an area of iodine sufficiency, and 86 patients >40 years of age with chronic hepatitis B. Levels of thyroid-stimulating hormone (TSH), free thyroxine (T(4)), and triiodothyronine (T(3)), as well as anti-thyroglobulin and anti-thyroid peroxidase antibodies, were measured. RESULTS:Mean TSH levels were higher (P = 0.001), and free T(3) and free T(4) levels were lower (P <0.0001), in patients with chronic hepatitis C than in all other groups. Patients with chronic hepatitis C were more likely to have hypothyroidism (13% [n = 82]), anti-thyroglobulin antibodies (17% [n = 108]), and anti-thyroid peroxidase antibodies (21% [n = 132]) than were any of the other groups. CONCLUSION:Both hypothyroidism and thyroid autoimmunity are more common in patients with chronic hepatitis C-even in the absence of cirrhosis, hepatocellular carcinoma, or interferon treatment-than in normal controls or those with chronic hepatitis B infection.
|Autori interni:||ANTONELLI, ALESSANDRO|
|Autori:||Antonelli A; Ferri C; Pampana A; Fallahi P; Nesti C; Pasquini M; Marchi S; Ferrannini E|
|Titolo:||Thyroid disorders in chronic hepatitis C|
|Anno del prodotto:||2004|
|Digital Object Identifier (DOI):||10.1016/j.amjmed.2004.01.023|
|Appare nelle tipologie:||1.1 Articolo in rivista|