Strong and weak anionic polystyrene/divinylbenzene ion exchange resins were investigated both as iodophores and as iodine/iodide ion removing agents in blood disinfection applications. Resin-iodine complexes were prepared, but no significant iodine release was observed in either distilled water or isotonic saline solution. However, all ion-exchange resin were able to remove almost quantitatively both iodine and iodide ions from water solutions. Crosslinked styrene/divinylbenzene resins are excellent adsorbents of polyaromatic viruscides, although their hydrophobicity is responsible for poor wettability in physiological fluids. Surface modification with hydrophilic reagents appeared a very promising strategy to overcome this drawback. A Merrifield–type chloromethylated resin and a highly crosslinked mesoporous resin (Lewatit 1064) with large surface area and content of unreacted vinyl groups were selected as starting materials. The Merrifield resin was modified by reaction of pendant chloromethyl groups with triethyleneglycol, tetraethyleneglycol, and β-cyclodextrin. Conversion of Lewatit double bonds into hydrophilic moieties was attempted by radical grafting of N-vinyl-2-pyrrolidinone, maleic anhydride, 2-hydroxyethyl methacrylate, acrylamide, and different PEG methacrylates. Addition of 2-mercaptoethanol and epoxidation were also investigated. All modified Merrifield resins showed a very low efficiency in the uptake of acridine viruscide, inspite of the huge increase of both wettability and water uptake. On the other hand, all modified Lewatit samples removed very quickly and almost quantitatively the viruscide from aqueous solutions, although only a few samples resulted very hydrophilic. In all cases, hydrophilicity and viruscide adsorbing capacity were maintained after heating at 180 °C to simulate pyrogen elimination.
Removal of Viruscide Agents by using Styrenic Resins
BARTOLOZZI, IRENE;SOLARO, ROBERTO;CHIELLINI, EMO
2004-01-01
Abstract
Strong and weak anionic polystyrene/divinylbenzene ion exchange resins were investigated both as iodophores and as iodine/iodide ion removing agents in blood disinfection applications. Resin-iodine complexes were prepared, but no significant iodine release was observed in either distilled water or isotonic saline solution. However, all ion-exchange resin were able to remove almost quantitatively both iodine and iodide ions from water solutions. Crosslinked styrene/divinylbenzene resins are excellent adsorbents of polyaromatic viruscides, although their hydrophobicity is responsible for poor wettability in physiological fluids. Surface modification with hydrophilic reagents appeared a very promising strategy to overcome this drawback. A Merrifield–type chloromethylated resin and a highly crosslinked mesoporous resin (Lewatit 1064) with large surface area and content of unreacted vinyl groups were selected as starting materials. The Merrifield resin was modified by reaction of pendant chloromethyl groups with triethyleneglycol, tetraethyleneglycol, and β-cyclodextrin. Conversion of Lewatit double bonds into hydrophilic moieties was attempted by radical grafting of N-vinyl-2-pyrrolidinone, maleic anhydride, 2-hydroxyethyl methacrylate, acrylamide, and different PEG methacrylates. Addition of 2-mercaptoethanol and epoxidation were also investigated. All modified Merrifield resins showed a very low efficiency in the uptake of acridine viruscide, inspite of the huge increase of both wettability and water uptake. On the other hand, all modified Lewatit samples removed very quickly and almost quantitatively the viruscide from aqueous solutions, although only a few samples resulted very hydrophilic. In all cases, hydrophilicity and viruscide adsorbing capacity were maintained after heating at 180 °C to simulate pyrogen elimination.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
