Some new 1,2,3-triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines were prepared starting from the corresponding 1,2,3-triazolo[4,5-d]pyrimidines via the formation of the 1,2,4-triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, triethyl orthoacetate and triethyl orthobenzoate to give the expected tricyclic derivatives 7, 8 and 9. Intramolecular cyclization of the ethoxycarbonylhydrazino derivatives 10 gave the tricyclic compounds 11 bearing an hydroxyl group in the 3 position. The v-triazolo-s-triazolopyrimidine derivatives were tested towards the A1 and A(2A) adenosine receptors in binding assays, but they did not show any receptor affinity.

1,2,3-TRIAZOLO[4,5-e]-1,2,4-TRIAZOLO[3,4-c]PYRIMIDINES

GIORGI, IRENE;MANERA, CLEMENTINA;
1999-01-01

Abstract

Some new 1,2,3-triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines were prepared starting from the corresponding 1,2,3-triazolo[4,5-d]pyrimidines via the formation of the 1,2,4-triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, triethyl orthoacetate and triethyl orthobenzoate to give the expected tricyclic derivatives 7, 8 and 9. Intramolecular cyclization of the ethoxycarbonylhydrazino derivatives 10 gave the tricyclic compounds 11 bearing an hydroxyl group in the 3 position. The v-triazolo-s-triazolopyrimidine derivatives were tested towards the A1 and A(2A) adenosine receptors in binding assays, but they did not show any receptor affinity.
G., Biagi; Giorgi, Irene; O., Livi; Manera, Clementina; V., Scartoni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/188415
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