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EnglishThe use of alginate microspheres for the production of polymeric bioactive scaffolds was analyzed. Encapsulation of the model proteins bovine serum albumin (BSA) and alkaline phosphatase (ALP) into alginate particles was performed by a single water-in-oil emulsification process. Scanning electron microscopy was used to study the size and shape of the produced particles. Drug loading was measured and in vitro tests were performed to evaluate the release of BSA and ALP from the particles. It was observed that spherical microparticles with smooth surface and a diameter in the 10-50 μm range were produced by working at room temperature conditions, while microparticles with a diameter in the 1-10 μm range were produced at low temperature.
| Titolo: | Alginate microspheres for the production of polymeric “bioactive” scaffolds |
| Autori interni: | |
| Anno del prodotto: | 2004 |
| Abstract: | The use of alginate microspheres for the production of polymeric bioactive scaffolds was analyzed. Encapsulation of the model proteins bovine serum albumin (BSA) and alkaline phosphatase (ALP) into alginate particles was performed by a single water-in-oil emulsification process. Scanning electron microscopy was used to study the size and shape of the produced particles. Drug loading was measured and in vitro tests were performed to evaluate the release of BSA and ALP from the particles. It was observed that spherical microparticles with smooth surface and a diameter in the 10-50 μm range were produced by working at room temperature conditions, while microparticles with a diameter in the 1-10 μm range were produced at low temperature. |
| Handle: | http://hdl.handle.net/11568/188788 |
| Appare nelle tipologie: | 4.1 Contributo in Atti di convegno |
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