Plasma samples from human cord blood, and fetuses, newborns, and adults of different mammalians species were analyzed by gel-filtration chromatography, to ascertain whether gamma-glutamyltransferase (GGT) fractions reflect liver maturation. Human cord blood plasma showed higher b-, m-, and s-GGT fraction as compared to adult women. In rat and mouse fetuses and in newborns, b-GGT was the most abundant fraction. As in adult humans, in adult rats, mice, rabbits, sheep, and mini pigs, f-GGT was the most abundant fraction. GGT fractions are a common feature of all mammalian species tested. Their pattern changes seem to reflect liver postnatal maturation, function.
|Autori:||Fierabracci, Vanna; Franzini, Maria; Baggiani, Angelo; Fornaciari, Irene; Burchielli, S; Urciuoli, P; Lamanna, R; Lapi, S; Nocchi, F; Iorio, Mc; Emdin, Michele; Pompella, Alfonso; Paolicchi, Aldo|
|Titolo:||Developmental variations of plasma gamma-glutamyltransferase fractions in humans and in laboratory mammalians|
|Anno del prodotto:||2012|
|Appare nelle tipologie:||1.1 Articolo in rivista|