Background: intima-media thickness (IMT) of common carotid artery (CCA) and carotid-femoral pulse wave velocity (PWV) are established markers of preclinical vascular disease, implemented in European guidelines for cardiovascular (CV) risk prediction. However, both are influenced mostly by age and blood pressure (BP), and their value as forerunner of atherosclerosis remains elusive. New US techniques improve accuracy of IMT measurements and provide estimates of local stiffness in the clinical setting. Aim of this study was to evaluate the association of high-resolution, radiofrequency-based (RF) US measurements of CCA IMT and local stiffness as well as PWV with age, BP and early disease state. Methods: 64 middle-age subjects free of clinical CV disease were studied, including 19 normals (NL, 9 men, age 43±9), 19 subjects with BP from high normal to mild hypertension (HT, 13 men, age 53±9), and 26 patients with recently diagnosed, well controlled, type 2 diabetes (DM2, 20 men, age 59±9). PWV was assessed by Complior (Alam, Paris). CCA far-wall IMT (Q-IMT®), diameter and distension (Q-AS®) were measured by a RF-based, fully automatic algorithm implemented in US system (MyLab 70, Esaote, Genova), 1.5 cm below the flow divider. The indices of CCA stiffness were calculated after BP calibration. Results: BP in NL, DM2 and HT was 107±12/74±8, 117±29/77±6 and 130±13/86±8 mmHg, respectively......

Radiofrequency-based estimates of local common carotid stiffness and intima-media thickness: implications for detecting early vascular involvement in hypertension and diabetes

PALOMBO, CARLO;MICCOLI, ROBERTO;DI BELLO, VITANTONIO;BALBARINI, ALBERTO
2011

Abstract

Background: intima-media thickness (IMT) of common carotid artery (CCA) and carotid-femoral pulse wave velocity (PWV) are established markers of preclinical vascular disease, implemented in European guidelines for cardiovascular (CV) risk prediction. However, both are influenced mostly by age and blood pressure (BP), and their value as forerunner of atherosclerosis remains elusive. New US techniques improve accuracy of IMT measurements and provide estimates of local stiffness in the clinical setting. Aim of this study was to evaluate the association of high-resolution, radiofrequency-based (RF) US measurements of CCA IMT and local stiffness as well as PWV with age, BP and early disease state. Methods: 64 middle-age subjects free of clinical CV disease were studied, including 19 normals (NL, 9 men, age 43±9), 19 subjects with BP from high normal to mild hypertension (HT, 13 men, age 53±9), and 26 patients with recently diagnosed, well controlled, type 2 diabetes (DM2, 20 men, age 59±9). PWV was assessed by Complior (Alam, Paris). CCA far-wall IMT (Q-IMT®), diameter and distension (Q-AS®) were measured by a RF-based, fully automatic algorithm implemented in US system (MyLab 70, Esaote, Genova), 1.5 cm below the flow divider. The indices of CCA stiffness were calculated after BP calibration. Results: BP in NL, DM2 and HT was 107±12/74±8, 117±29/77±6 and 130±13/86±8 mmHg, respectively......
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/188869
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