AIM: The creation of a physician-administered questionnaire to screen patients with Systemic Lupus Erythematosus (SLE) for the presence of symptoms suggestive of neuropsychiatric involvement (NPSLE). METHODS: The development of the questionnaire followed three phases. First, a list of manifestations was prepared based on the ACR case definitions for NPSLE. A first questionnaire was constructed including 119 items. To reduce their number, a Delphi analysis was carried out and a second questionnaire with 62 questions was developed. This questionnaire was administered to 139 patients with SLE (58 with NPSLE: 29 active, 29 inactive; and 81 without NPSLE: 39 active, 42 inactive). Questions relevant to the screening of patients were selected on the basis of the receiver operating characteristic (ROC) curve analysis. RESULTS: Twenty-seven questions concerning central nervous system and psychiatric manifestations were found to be relevant; the remaining could be eliminated without significantly affecting AUC. The area under the ROC curve (AUC) was 0.69 (95% CI 0.61-0.78). A score above 17 was considered as suggestive of the presence of NPSLE with a sensitivity of 92.9% (95% CI 85.1-97.3 %) and specificity of 25.4% (95% CI 14.7-39.00 %). CONCLUSIONS: This questionnaire could represent a 'core set' of questions that could help in clinical practice to identify patients with neuropsychiatric symptoms requiring further evaluation.
|Autori:||MOSCA M; GOVONI M; TOMIETTO P; ARINGER M; BOUMPAS D; CERVERA R; CONTI F; D'CRUZ D; DORIA A; DE LA FUENTE D; GALEAZZI M; HOUSSIAU F; HUIZINGA TW; KHAMASHTA MA; INES L; DUARTE C; COUTO M; MERONI P; MONTECUCCO C; NORKUVIENE E; RIEMEKASTEN G; RIOS V; SCHNEIDER M; SHOENFELD Y; STEUP-BEEKMAN GM; SZMYRKA-KACZMAREK M; TANI C; TINCANI A; TZIOUFAS AG; VOLL R; BENCIVELLI W.; SALAFFI F; BOMBARDIERI S|
|Titolo:||The development of a simple questionnaire to screen patients with SLE for the presence of neuropsychiatric symptoms in routine clinical practice|
|Anno del prodotto:||2011|
|Appare nelle tipologie:||1.1 Articolo in rivista|