The synthesis of new 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3-aryloxycarbonyl derivatives of pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their binding affinities at the central benzodiazepine receptor (BZR) are reported. The 3-propynyl ester 10 and the 3-benzyl ester 16, having the best affinity values, were chosen for in, vivo testing.
Benzodiazepine receptor (BZR) ligands. 5. New 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3-aryloxy-carbonyl derivatives of pyrazolo [5,1-c][1,2,4]benzotriazine 5-oxides: A study on the 3-ester function modification
COSTA, BARBARA;MARTINI, CLAUDIA;LUCACCHINI, ANTONIO;
1999-01-01
Abstract
The synthesis of new 3-alkyloxycarbonyl-, 3-cyclo-alkyloxycarbonyl-, 3-aryloxycarbonyl derivatives of pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides and their binding affinities at the central benzodiazepine receptor (BZR) are reported. The 3-propynyl ester 10 and the 3-benzyl ester 16, having the best affinity values, were chosen for in, vivo testing.File in questo prodotto:
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