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EnglishThree-dimensional wet-spun microfibrous meshes of a star poly(ε-caprolactone) were developed as potential scaffolds endowed with antimicrobial activity. The in vitro release kinetics of the meshes, under physiological conditions, was initially fast and then a sustained release for more than one month was observed. Cell cultures of a murine pre-osteoblast cell line showed good cell viability and adhesion on the wet-spun star poly(ε-caprolactone) fiber scaffolds. These promising results indicate a potential application of the developed meshes as engineered bone scaffolds with antimicrobial activity
| Autori interni: | |
| Autori: | Puppi D; Dinucci D; Bartoli C; Mota C; Migone C; Dini F; Barsotti G; Carlucci F; Chiellini F |
| Titolo: | Development of 3D wet-spun polymeric scaffolds loaded with antimicrobial agents for bone engineering |
| Anno del prodotto: | 2011 |
| Digital Object Identifier (DOI): | 10.1177/0883911511415918 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11568/189492
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