From the roots of Vismia guineensis 23 structurally related compounds were isolated and identified. Ten of them are new constituents, namely 3-O- (2-hydroxy-3-methylbut-3-enyl)-emodin (1); 3-O-(2-methoxy-3-methylbut-3- enyl)-emodin (2); 1,8-dihydroxy-3-(2-methoxy-3-methylbut-3-enyloxy)-6- methylxanthone (3); 1,8-dihydroxy-3-geranyloxy-6-methylxanthone (4); 1,8- dihydroxy-3-isoprenyloxy-6-methylxanthone (5); 1,8-dihydroxy-3-(3,7-dimethyl- 7-methoxyoct-2-enyloxy)-6-methylxanthone (6); 3-O-(E-3-hydroxymethylbut-2- enyl)-emodin (7); 3-O-(3-hydroxymethyl-4-hydroxybut-2-enyl)-emodin (8); 1,8- dihydroxy-3-(E-3-hydroxymethylbut-2-enyloxy)-6-methylxanthone (9); and 1,8- dihydroxy-3-(3-hydroxymethyl-4-hydroxybut-2-enyloxy)-6-methylxanthone (10). Their structures were established by means of EIMS and a combination of homonuclear and heteronuclear 2D NMR techniques. Furthermore, an in vitro preliminary screening of antimitotic activity of all the isolated compounds was also evaluated.
|Autori:||A.R. BILIA; A. WARSAME YUSUF; A. BRACA; A. KEITA; I. MORELLI|
|Titolo:||New prenylated Quinones from Vismia guineensis|
|Anno del prodotto:||2000|
|Digital Object Identifier (DOI):||10.1021/np990226j|
|Appare nelle tipologie:||1.1 Articolo in rivista|