Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var, heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3 beta -O-trans-p-coumaroyl alphitolic acid 3, 3 beta -O-cis-p-coumaroyl alphitolic acid 4, 3 beta -O-trans-p-coumaroyl maslinic acid 5, 3 beta -O-cis-p-coumaroyl maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method. Compounds 2, 3, 5, and 6 showed antimicrobial activity on Cram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.

Antimicrobial triterpenoids from Licania heteromorpha

BRACA, ALESSANDRA;MORELLI, IVANO;
2000

Abstract

Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var, heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3 beta -O-trans-p-coumaroyl alphitolic acid 3, 3 beta -O-cis-p-coumaroyl alphitolic acid 4, 3 beta -O-trans-p-coumaroyl maslinic acid 5, 3 beta -O-cis-p-coumaroyl maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method. Compounds 2, 3, 5, and 6 showed antimicrobial activity on Cram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.
Braca, Alessandra; Morelli, Ivano; J., Mendez; L., Battinelli; L., Braghiroli; G., Mazzanti
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/189785
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