Cleviolide 1 has been synthesized in 73 % overall yield by a short reaction sequence involving the preparation of 4-methyl-1-trimethylsilylpent-3-en-1-yne 7 from trimethylsilylethynylzinc chloride 6 and 1-bromo-2-methylpropene 5, the direct conversion of 7 into the corresponding 1-tributylstannyl derivative 8 and the Pd-catalysed reaction of this organotin derivative with 4-bromofuran-2(5H)-one 10.

A concise and efficient novel synthesis of cleviolide

ROSSI, RENZO;BELLINA, FABIO;
1999-01-01

Abstract

Cleviolide 1 has been synthesized in 73 % overall yield by a short reaction sequence involving the preparation of 4-methyl-1-trimethylsilylpent-3-en-1-yne 7 from trimethylsilylethynylzinc chloride 6 and 1-bromo-2-methylpropene 5, the direct conversion of 7 into the corresponding 1-tributylstannyl derivative 8 and the Pd-catalysed reaction of this organotin derivative with 4-bromofuran-2(5H)-one 10.
1999
Rossi, Renzo; Bellina, Fabio; Biagetti, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11568/190462
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