Cleviolide 1 has been synthesized in 73 % overall yield by a short reaction sequence involving the preparation of 4-methyl-1-trimethylsilylpent-3-en-1-yne 7 from trimethylsilylethynylzinc chloride 6 and 1-bromo-2-methylpropene 5, the direct conversion of 7 into the corresponding 1-tributylstannyl derivative 8 and the Pd-catalysed reaction of this organotin derivative with 4-bromofuran-2(5H)-one 10.
Autori interni: | |
Autori: | Rossi, Renzo; Bellina, Fabio; Biagetti, M. |
Titolo: | A concise and efficient novel synthesis of cleviolide |
Anno del prodotto: | 1999 |
Digital Object Identifier (DOI): | 10.1080/00397919908085969 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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