Cleviolide 1 has been synthesized in 73 % overall yield by a short reaction sequence involving the preparation of 4-methyl-1-trimethylsilylpent-3-en-1-yne 7 from trimethylsilylethynylzinc chloride 6 and 1-bromo-2-methylpropene 5, the direct conversion of 7 into the corresponding 1-tributylstannyl derivative 8 and the Pd-catalysed reaction of this organotin derivative with 4-bromofuran-2(5H)-one 10.
|Autori:||Rossi, Renzo; Bellina, Fabio; Biagetti, M.|
|Titolo:||A concise and efficient novel synthesis of cleviolide|
|Anno del prodotto:||1999|
|Digital Object Identifier (DOI):||10.1080/00397919908085969|
|Appare nelle tipologie:||1.1 Articolo in rivista|