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EnglishInadequate antigen presentation and/or suboptimal immunogenicity are considered major causes in the failure of human immunodeficiency vaccine to adequately protect against wild-type virus. Several approaches have been attempted to circumvent these hurdles. Here we reviewed some recent vaccinal strategies tested against the feline immunodeficiency virus and focused on: (i) improving antigen presentation by taking advantage of the exquisite ability of dendritic cells to process and present immunogens to the immune system; (ii) boosting immune responses with vaccinal antigens presented in a truly native conformation by the natural target cells of infection. Significance of the studies, possible correlates of protection involved, and implications for developing anti-human immunodeficiency virus vaccines are discussed. (C) 2009 Elsevier B.V. All rights reserved.
| Autori interni: | FREER, GIULIA [Writing – Original Draft Preparation] | |
| Autori: | Pistello, Mauro; Conti, F; Vannucci, L; Freer, Giulia | |
| Titolo: | Novel approaches to vaccination against the feline immunodeficiency virus | |
| Anno del prodotto: | 2010 | |
| Abstract: | Inadequate antigen presentation and/or suboptimal immunogenicity are considered major causes in the failure of human immunodeficiency vaccine to adequately protect against wild-type virus. Several approaches have been attempted to circumvent these hurdles. Here we reviewed some recent vaccinal strategies tested against the feline immunodeficiency virus and focused on: (i) improving antigen presentation by taking advantage of the exquisite ability of dendritic cells to process and present immunogens to the immune system; (ii) boosting immune responses with vaccinal antigens presented in a truly native conformation by the natural target cells of infection. Significance of the studies, possible correlates of protection involved, and implications for developing anti-human immunodeficiency virus vaccines are discussed. (C) 2009 Elsevier B.V. All rights reserved. | |
| Digital Object Identifier (DOI): | 10.1016/j.vetimm.2009.10.008 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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