The present study explored the possible relationships between impulsivity, gender, and a peripheral serotonergic marker, the platelet serotonin (5-HT) transporter (SERT), in a group of 32 healthy subjects. The impulsivity was measured by means of the Barratt Impulsivity Scale, version 11 (BIS-11), a widely used self-report questionnaire, and the platelet SERT was evaluated by means of the specific binding of (3)H-paroxetine ((3)H-Par) to platelet membranes, according to standardized protocols. The results showed that women had a higher BIS-11 total score than men, and also higher scores of two factors of the same scale: the motor impulsivity and the cognitive complexity. The analysis of the correlations revealed that the density of the SERT proteins, as measured by the maximum binding capacity (B(max)) of (3)H-Par, was significantly and positively related to the cognitive complexity factor, but only in men. Men showed also a significant and negative correlation with the dissociation constant, Kd, of ((3)H-Par) binding, and the motor impulsivity factor. These findings suggest that women are generally more impulsive than men, but that the 5-HT system is more involved in the impulsivity of men than in that of women.
|Autori:||MARAZZITI D; BARONI S; MASALA I; GOLIA F; CONSOLI G; MASSIMETTI G; PICCHETTI M; CATENA DELL'OSSO M; GIANNACCINI G; BETTI L; LUCACCHINI A; CIAPPARELLI A|
|Titolo:||Impulsivity, gender, and the platelet serotonin transporter in healthy subjects|
|Anno del prodotto:||2010|
|Appare nelle tipologie:||1.1 Articolo in rivista|