Alkenyl aziridines can be successfully arylated in a three-component coupling triggered by in situ generated benzyne with a simple copper catalyst (CuI-PPH3), without the need of any palladium salts. The corresponding allylic amines can be obtained with good to high regioselectivity in mild reaction conditions with a variety of cyclic and acyclic alkenyl aziridines . A new domino reaction with ethyl propiolate to give tetrahydrophenanthridine was also found.

Copper-Catalyzed Arylation of Alkenyl Aziridines via Three-Component Coupling Reaction involving Alkynes and Benzyne

CROTTI, PAOLO;PINESCHI, MAURO
2012

Abstract

Alkenyl aziridines can be successfully arylated in a three-component coupling triggered by in situ generated benzyne with a simple copper catalyst (CuI-PPH3), without the need of any palladium salts. The corresponding allylic amines can be obtained with good to high regioselectivity in mild reaction conditions with a variety of cyclic and acyclic alkenyl aziridines . A new domino reaction with ethyl propiolate to give tetrahydrophenanthridine was also found.
Berti, F; Crotti, Paolo; Cassano, G; Pineschi, Mauro
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/192993
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