Alkenyl aziridines can be successfully arylated in a three-component coupling triggered by in situ generated benzyne with a simple copper catalyst (CuI-PPH3), without the need of any palladium salts. The corresponding allylic amines can be obtained with good to high regioselectivity in mild reaction conditions with a variety of cyclic and acyclic alkenyl aziridines . A new domino reaction with ethyl propiolate to give tetrahydrophenanthridine was also found.
|Autori:||Berti, F; Crotti, Paolo; Cassano, G; Pineschi, Mauro|
|Titolo:||Copper-Catalyzed Arylation of Alkenyl Aziridines via Three-Component Coupling Reaction involving Alkynes and Benzyne|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1055/s-0031-1290467|
|Appare nelle tipologie:||1.1 Articolo in rivista|