Type 2 Von Willebrand disease (VWD) is a severe coagulopathy occurring in the Deutsch-Drahthaar dog (or German Wirehaired Pointer, DD/GWP). Recently, a causative recessive mutation has been identified, and a DNA test is now available for individual screening. The genotype distribution (clear, carrier, and affected dogs) was investigated in 1855 DD/GWP dogs using data collected by the DD DNA-VWD-Databank in several European countries. 1704 (91.8%) DD/GWP dogs were genotypically clear of the VWD mutation, 144 (7.8%) were carriers, and seven (0.4%) were affected. The estimated disease allele frequency was highest in Germany and Sweden (almost 5%), and about 1% in Denmark, Finland and Norway. The Hardy–Weinberg equilibrium was tested in the German sample, and showed no evidence of deviation.
GAVAZZA, ALESSANDRA (Corresponding)
|Autori:||Gavazza A; Presciuttini S; Keuper H; Lubas G|
|Titolo:||Estimated prevalence of canine Type 2 Von Willebrand disease in the Deutsch-Drahthaar (German Wirehaired Pointer) in Europe.|
|Anno del prodotto:||2012|
|Digital Object Identifier (DOI):||10.1016/j.rvsc.2012.06.010|
|Appare nelle tipologie:||1.1 Articolo in rivista|