In continuing the search for more effective 5-arylidene-4-thiazolidinones as aldose reductase inhibitors, a new set of suitably substituted compounds (4, 5 and 8) was explored. Acetic acids 5, particularly 5a and 5h, proved to be interesting inhibitors of the enzyme as well as excellent antioxidant agents that are potentially able to counteract the oxidative stress associated with both diabetic complications as well as other pathologies. Molecular docking experiments supported SAR studies.

Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications

DEL CORSO, ANTONELLA;CAPPIELLO, MARIO;MURA, UMBERTO;LA MOTTA, CONCETTINA;DA SETTIMO PASSETTI, FEDERICO
2011

Abstract

In continuing the search for more effective 5-arylidene-4-thiazolidinones as aldose reductase inhibitors, a new set of suitably substituted compounds (4, 5 and 8) was explored. Acetic acids 5, particularly 5a and 5h, proved to be interesting inhibitors of the enzyme as well as excellent antioxidant agents that are potentially able to counteract the oxidative stress associated with both diabetic complications as well as other pathologies. Molecular docking experiments supported SAR studies.
Ottanà, R; Maccari, R; Giglio, M; DEL CORSO, Antonella; Cappiello, Mario; Mura, Umberto; Cosconati, S; Marinelli, L; Novellino, E; Sartini, S; LA MOTTA, Concettina; DA SETTIMO PASSETTI, Federico
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11568/193809
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