Abstract AIM: To describe the kinetics of serum inflammatory markers after a course of treatment comprising surgical and non-surgical treatment of chronic periodontitis (CP). MATERIAL AND METHODS: Fourteen CP cases received full-mouth non-surgical treatment and, after 6 months, at least two surgical sessions. Blood samples were collected at various time-points after treatment. Blood markers of systemic inflammation/coagulation including leucocyte counts, C-reactive protein (CRP), serum amyloid-A (SAA) and D-dimers and renal function (cystatin C) were determined using high-sensitivity assays. RESULTS: Periodontal treatment resulted in substantial reductions of the number of pockets, gingival bleeding and plaque at 3 and 6 months after non-surgical therapy (p<0.001). Surgical therapy led to an additional reduction of periodontal pockets (p<0.01). Marked increases in the serum levels of CRP and SAA were noted 24 h after non-surgical therapy (p<0.01) and periodontal surgeries (p<0.05). D-dimer levels increased drastically 24 h after non-surgical therapy (p<0.05). The drastic increase of CRP after non-surgical therapy was greater than both the surgical therapy sessions (p<0.05). CONCLUSIONS: Patients undergoing periodontal treatment experience perturbations of systemic inflammation of a greater magnitude after non-surgical than surgical periodontal therapy.
|Autori interni:||GRAZIANI, FILIPPO|
|Autori:||GRAZIANI F; CEI S; TONETTI M; PAOLANTONIO M; SERIO R; SAMMARTINO G; GABRIELE M; D'AIUTO F|
|Titolo:||Systemic inflammation following non-surgical and surgical periodontal therapy|
|Anno del prodotto:||2010|
|Appare nelle tipologie:||1.1 Articolo in rivista|