We report on a 22-year-old female who developed aplastic anemia after administration of phenobarbital for 6 years. Being refractory to steroid and anti-lymphocyte serum, the patient received allogeneic stem cell transplantation, achieving complete remission. We discuss here the potential mechanisms by which phenobarbital and other anti-epileptic drugs can cause aplastic anemia and review the literature for previous case reports and epidemiological studies.
|Autori:||FOCOSI D; KAST RE; BENEDETTI E; PAPINESCHI F; GALIMBERTI S; PETRINI M|
|Titolo:||Phenobarbital-associated bone marrow aplasia: a case report and review of the literature|
|Anno del prodotto:||2008|
|Appare nelle tipologie:||1.1 Articolo in rivista|