Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system. (c) 2007 Elsevier Ltd. All rights reserved.
1-aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems
GIANNACCINI, GINO;BETTI, LAURA;LUCACCHINI, ANTONIO
2007-01-01
Abstract
Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system. (c) 2007 Elsevier Ltd. All rights reserved.File in questo prodotto:
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