Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system. (c) 2007 Elsevier Ltd. All rights reserved.
|Autori:||Gelmi ML; Caputo F; Clerici F; Pellegrino S; Giannaccini G; Betti L; Fabbrini L; Schmid L; Palego L; Lucacchini A|
|Titolo:||1-aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems|
|Anno del prodotto:||2007|
|Digital Object Identifier (DOI):||10.1016/j.bmc.2007.09.004|
|Appare nelle tipologie:||1.1 Articolo in rivista|