Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading. Journal of Cerebral Blood Flow & Metabolism (2010)30,895-899; doi: 10.1038/jcbfm.2010.27; published online 24 February 2010
Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[(18)F]FDG study in Zucker and ZDF rats
BELCARI, NICOLA;DEL GUERRA, ALBERTO;
2010-01-01
Abstract
Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading. Journal of Cerebral Blood Flow & Metabolism (2010)30,895-899; doi: 10.1038/jcbfm.2010.27; published online 24 February 2010I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
